4A 4Hi 4Lo are all exactly the same as far as IWE is concerned.
It's easier to get your head around if you ever had a truck with manual locking hubs. The IWE is nothing more than a hub that is locked/unlocked via vacuum, rather than you getting out of the truck and turning the lock yourself.
So it is very much a separate thing than transfer case settings. You could manually lock your hub in 2WD, but since the transfer case wasn't "transferring" torque to the front differential, you were still just driving the rear wheels, albeit you ARE turning the front axles since the hub is locked. (a small added rotational load)
IWE deletes are very similar to just leaving those old manual hubs locked full time. And exactly the same thing as just nixing Ford's vacuum to the IWE altogether.
4A is designed to be used on high traction conditions, so there's no risk driving in 4A. My Powerboost automatically engages 4A if you switch to Sport Mode. Think about that for a second.
I think Ford should include 4A on all 4x4 F150's.