I have been using synthetics for over 35 years and Mobile 1 for 25 years. I took the heads off a car that had 300,000+ miles on it. You could see the original factory cross-hones in the cylinder wall and there was no ridge at the top of the bore. The engine didn't use a drop of oil whatsoever.
I also agree that it is a good idea to break the engine in with regular oil first to seat the rings. I would do frequent oil changes and switch to synthetic anywhere between 5,000-10,000 miles. I just bought my truck last weekend, but I plan to do my first oil & filter change at 1,000 miles, another at 2,500 and at 5,000 switch to full synthetic. While it's on warranty, I will be using Ford's full synthetic ... so they don't have any excuses to void my warranty.
Once my warranty is over, I will switch to Mobil 1 again.