I went down this rabbit hole recently. This is not advice, but merely my thought pattern. If anyone has anything to add or correct, please do.
External oil and coolant leaks on driver side turbo. Turbo oil flange completely rusted out exposing the gasket and created a slow leak at the oil return line. Unfortunately, this is a big thumbs up to get a 5.0 coyote or other non-turbo engine from the f-series if living in the rust belt. We apparently spray spent beer products on our roads, its tasty, but eats vehicles like a rabid pacman... Hopefully its still getting enough oil feed to not self destruct. I ended up purchasing OEM BW from Full-race for a 2016 f150 3.5l ecoboost. Also purchased upgraded coolant lines, turbo adapters, and manifolds. Installed a larger 3in freakoboost exhaust from fullrace as well. I have 34in Ko3, add-a-leaf, eibach rear shocks. 115k miles with neurotic maintenance scheduling. Complete stock engine with repairs done as needed. Have not installed the turbos or manifolds as it is -6c atm here in VT and I spend all my free time skiing.
After researching, it seems there are other variables that can occur with upgrading turbo size and power. This increases the price point. For effective use I found one would be looking at upgraded programming, intercooler, BOV, MAP sensor to 3 bar, catch can install, and exhaust. Are they all needed, some needed, none needed? Not sure, but for reliability and longevity I would want all of these upgrades with the Garret upgrade. Any upgrade with OEM BW is now going to be an added bonus, but not an absolute need.
Even though it says the Garret can be run with stock tune and OEM system, I was still on edge trusting my PCM brain to do the work and keep everything at check. By keeping OEM sized turbos its not going to be a racecar or tow monster, it is going to still run hot, but I will be maintaining factory conditions and staying within engine parameters for longevity, ease of maintenance, and decreasing variability in system. I now have back-up parts in case the new turbos malfunction and if I decide to do some upgrades it will help with heat soak, but not overpower or cause any damage to other engine parts. Some will continue to claim that a larger turbo will increase gas mileage and decrease boost psi for same air volume, I agree this is true, from theory and researching turbo design online. However, I do not know how this engine and all its components will continue to work with changes and age, and if there is a hiccup with the OEM setup, will it over spool and blow up the turbine, cause a seal/gasket malfunction, leak in another area?... I am not a turbo expert or a mechanic, just a dude with a wrench.
If I had $$$ and didn't spend so much time throwing my body off cliffs, through trees, and down snow covered chutes I would have probably upgraded to Garret with additional peripheral parts to better support the system. The future awaits, but by the look of it investing in a sturdy cart, a good stallion, and a team of good natured mules may be around the bend...